USE OF AT LEAST ONE DRUG BASED ON LICORICE, ANTIDOTE OBTAINED FROM IT, AND APPLICATION OF SPECIFIED ANTIDOTE

摘要

FIELD: toxicology.;SUBSTANCE: group of inventions relates to the use of means to reduce the toxic effect of at least one polypeptide fungitoxin selected from enniatin A, enniatin A1, enniatin B, enniatin B1, enniatin B2 or enniatin B3, bovericin and apicidin, in agricultural products. The use of at least one licorice preparation selected from a group including flour, water extract, water/ethanol extract, water dry extract and water/ethanol dry extract from a whole licorice plant or from licorice roots, with the licorice preparation containing 4-10 wt %/ wt. glycyrrhizic acid, optionally together with at least one excipient for oral administration, to reduce the toxic effect of at least one polypeptide fungitoxin selected from a group including enniatins selected from the group of enniatin A, enniatin A1, enniatin B, enniatin B1, enniatin B2 or enniatin B3, bovericin and apicidin, in agricultural products. The use of an antidote comprising at least one licorice preparation selected from a group including flour, water extract, water / ethanol extract, water dry extract, and water/ethanol dry extract from a whole licorice plant or from the roots, with the licorice preparation containing 4-10 wt %/ wt. glycyrrhizic acid, to obtain a drug for oral use for the prevention and/or treatment of intoxication with polypeptide fungitoxins, where intoxication with polypeptide fungitoxins is caused by polypeptide fungitoxins selected from a group including enniatin A, enniatin A1, enniatin B, enniatin B1, enniatin B2 or enniatin B3, bovericin or apicidin.. ;EFFECT: use of the above licorice preparations and antidote is effective in reducing the toxic effect of at least one polypeptide fungitoxin selected from enniatin A, enniatin A1, enniatin B, enniatin B1, enniatin B2 or enniatin B3, bovericin and apicidin, in agricultural products. ;9 cl, 7 tbl, 5 ex