An Immunotherapeutic agent composition for preventing or treating brain cancer comprising metformin as an active reagent

摘要

The present invention relates to a method for screening an immunotherapeutic agent and an immunotherapeutic agent for the prevention or treatment of brain cancer, wherein the immunotherapeutic composition of the present invention reduces the amount of oxygen consumed in brain cancer cells, resulting in hypoxia occurring in immune cells infiltrating brain cancer. Can be improved, and thereby the anti-tumor immune response of γδ T cells infiltrated into brain cancer and the ability to directly target and kill brain cancer cells are restored, and thus brain cancer can be treated very effectively. Furthermore, immunotherapy can be screened very effectively by measuring the expression level of genes expressed in γδ T cells.