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HTP platform for the genetic engineering of Chinese hamster ovary cells
HTP platform for the genetic engineering of Chinese hamster ovary cells
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机译:中国仓鼠卵巢细胞基因工程的HTP平台
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摘要
Presented herein is a high-throughput (HTP) genomic engineering platform for improving the production of therapeutic proteins in Chinese hamster ovary (CHO) cells. The disclosed HTP genomic engineering platform is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. The platform utilizes a unique suite of HTP genetic engineering tools to explore the genomic landscape associated with therapeutic protein production pathways, in order to unravel the biological drivers and disentangle the uncharacterized genetic architecture responsible for optimizing therapeutic protein production in CHO cells.
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