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LYOPHILIZED PREPARATION OF VACCINE CONTAINING ALUMINUM ADJUVANT AND PREPARATION METHOD AND USE THEREFOR
LYOPHILIZED PREPARATION OF VACCINE CONTAINING ALUMINUM ADJUVANT AND PREPARATION METHOD AND USE THEREFOR
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机译:冻干制备含铝助剂的疫苗和制备方法和用途
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摘要
A lyophilized preparation of a vaccine containing an aluminum adjuvant, and a preparation method and a use therefor. The aluminum salt vaccine lyophilized preparation contains: a vaccine antigen, an adjuvant, a lyoprotectant, and a nanoparticle or a microparticle formed from compounding of an anionic polymer or a derivative thereof with an aluminum salt. The lyophilization method avoids large amounts of aggregation of aluminum hydroxide in the vaccine, and reduces reduction to antigen activity. The present invention is able to improve the stability of a vaccine in a lyophilization process and a storage process, and can cause the vaccine to not require cold-chain transportation. The invention is low cost, saves energy, and particularly solves the technical problem of difficulty in guaranteeing cold-chain delivery in remote areas.
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