The present invention concerns a method for monitoring a hadron beam during hadron-therapy treatment of a subject comprising tumour cells labelled with a radiopharmaceutical product, in which the hadron beam comprises a plurality of discrete hadron bursts, the method comprising the following steps: when a burst impacts on the subject, detecting the prompt gamma (111) generated by the interaction of the hadrons of the burst with the tissues of the subject by means of a Compton telescope and reconstructing an image (112) of the interaction volume; when no burst impacts on the subject, extracting the position of the tumour cells (121) labelled with the radiopharmaceutical product by means of the Compton telescope and reconstructing an image of the total volume of the tumour (122); comparing the image of the interaction volume and the image of the total volume of the tumour (131) so as to locate the measured interaction volume relative to the measured total volume of the tumour.
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