BLOOD-TISSUE BARRIER IN VITRO MODEL AND METHOD FOR EVALUATING BLOOD-TISSUE BARRIER TRANSPORTABILITY OF DRUG

摘要

This blood-tissue barrier in vitro model contains: a collagen vitrigel membrane; human vascular endothelial cells disposed on the top surface of this collagen vitrigel membrane; organ-derived cells disposed on the bottom surface of this collagen vitrigel membrane; and a culture solution. The human vascular endothelial cells are dependent on the organ-derived cells and are capable of differentiating into the vascular endothelial cells of that organ.