BOSENTAN MONOHYDRATE LOADED LIQUID SELF NANOEMULSIFYING DRUG CARRIER SYSTEM AND TABLET FORMULATION

摘要

The invention relates to converting the powder form into a solid tablet form by adsorbing the liquid self nanoemulsifying drug delivery system (SNEDDS) containing bosentan monohydrate to an adsorbent carrier (S-SNEDDS). Liquid SNEDD system consists of certain proportions of Glyceryl monolinoleate (Maisine®) - Polyoxyl 40 hydrogenated castor oil (Cremophor®RH 40) - Caprilocaproyl polyoxyl-8 glycerides (Labrasol®). In the solidification of the liquid system, magnesium aluminometasilicate (Neusilin® US2) was used as an adsorbent and formed into a tablet by direct compression method.