NANOPARTICLE COMPOSITE SHOWING IMPROVED ENDOCYTOSIS EFFICIENCY THROUGH SURFACE MODIFICATION USING LIPID AND MANUFACTURING METHOD THEREFOR

摘要

The present disclosure relates to a nanoparticle complex that is taken into cells to be used for the treatment of diseases, and a method of manufacturing the same. More particularly, the present disclosure relates to a nanoparticle complex and a method of manufacturing the same using a top-down process. In the top-down process, surfaces of nanoparticles are modified with a lipid-based material having high stability and excellent biocompatibility, thereby improving cellular uptake. A lipid structure having a tube shape is bonded to a portion of the surface of the nanoparticle so that the nanoparticle complex undergoes endocytosis, directly penetrates a cell membrane, and is effectively taken into spheroid-type tumor cells. The lipid structure is not directly attached to the nanoparticle, lipid-based lipidomes (such as bubbles and liposomes) are bonded to the nanoparticles, and mechanical force is applied thereto to thus crush the lipidomes, so that the lipid structure is formed on the surface of the nanoparticles. Since a top-down process is used, it is possible to easily mass-produce the nanoparticle complex.