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Nucleic acid catenane with a linking duplex biosensor for detection of a microorganism target
Nucleic acid catenane with a linking duplex biosensor for detection of a microorganism target
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机译:具有连接双链体传感器的核酸脱替萘,用于检测微生物靶标
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摘要
The present application is directed to biosensors and methods for detecting a microorganism target in a sample using a mechanically interlocked nucleic acid catanane, wherein an enzyme from the microorganism target or that is activated by a molecule from the microorganism target cleaves a linkage in a first single-stranded nucleic acid ring of the catanane structure, allowing rolling-circle amplification to occur and the presence of rolling-circle amplification products indicates the presence of the microorganism in the sample.
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