MOLECULAR SIGNATURES OF RADIATION SENSITIVITY IN TUMORS, AND METHODS OF USE THEREOF

摘要

The present invention relates to molecular signatures in genomic DNA that are associated with sensitivity of tumors, such as HPV-associated tumors, to treatment with radiation therapy. The present invention provides methods of analyzing tissue samples, or DNA obtained therefrom, to assess the presence of such molecular signatures, methods of predicting whether a tumor in a subject will be sensitive to treatment with radiation therapy based on the presence of such signatures, and methods of treating subjects with radiation therapy if such signatures are present.