NOVEL HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS AND THEIR USE IN TARGETING ONCOLOGICAL DISEASES SENSITIVE TO PYRIMIDINE STARVATION

摘要

The invention relates to compounds of formulae (I) and (II) which are novel inhibitors of human dihydroorotate dehydrogenase (hDHODH), pharmaceutical compositions containing the aforementioned inhibitors as well as their use in the treatment of TUMOR diseases related, in particular acute myelogenous leukemia (AML), triple- negative breast cancer, PTEN-mutant tumors, and KRAS-driven tumors.