Peptide inhibitors of the interleukin 23 receptor, and their use for treating inflammatory diseases

摘要

The present invention relates to novel interleukin 23 receptor peptide inhibitors and related compositions using these peptide inhibitors to treat or prevent various diseases and disorders including inflammatory bowel disease and Provide a method. In a specific embodiment according to the present invention, the peptide inhibitor has the amino acid sequence: [Palm]-[isoGlu]-[PEG4]-[Pen] -NTWQ- [Pen]-[Phe [4- (2- aminoethoxy)] - [2-Nal] - [Aib] - [Lys (Ac)] - having NNNH _2. [Selection] Figure 1