Prediction of EGFR inhibitor effect by BRAF mutation detection

摘要

PROBLEM TO BE SOLVED To develop a novel marker for predicting treatment effect of EGFR inhibitor of BRAF mutation in order to more accurately judge adaptability to EGFR inhibitor.A method for detecting a mutation in human BRAF that predicts a therapeutic effect of an EGFR inhibitor of the present invention comprises using a patient's biological sample to detect mutations in human BRAF protein G469, L485 , Q 524, L 525, D 594 and V 600, wherein the tumor in which mutation of said gene has been detected is detected in said tumor, It is not suitable for treatment with BRAF-mediated signal transduction system inhibitors.