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Treating degenerative dementia with low intensity focused ultrasound pulsation (LIFUP) device

机译:用低强度聚焦超声波脉动(LIFUP)装置治疗退行性痴呆

摘要

Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam is directed at a target area of the brain to promote removal of substances that accumulate in the interstitial pathways that are at least partially responsible for the degenerative dementia. In one example, the target area of the brain may comprise the hippocampus and the degenerative dementia may be Alzheimer's disease. The ultrasonic beam may stimulate brain tissue at a frequency that corresponds to a naturally occurring deep sleep burst frequency of neurons and subsequent astrocyte activation patterns that drive a convective process responsible for brain solute disposal. For example, the transducer may generate a burst frequency of between 1-4 hertz to stimulate deep sleep brain functions that help remove amyloid plaque.
机译:超声能量用于治疗退行性痴呆。超声换能器光束的焦点涉及大脑的靶区域,以促进在至少部分地负责退行性痴呆的间质途径中消除积聚的物质。在一个实例中,脑的靶区域可包含海马,并且退行性痴呆可能是阿尔茨海默病。超声波束可以以频率刺激脑组织,该频率对应于神经元的天然存在的深度睡眠爆发频率和随后的星形胶质细胞激活图案,其驱动负责脑溶质处理的对流过程。例如,换能器可以产生1-4赫兹之间的突发频率以刺激有助于去除淀粉样蛋白斑块的深度睡眠脑功能。

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