Antigen-binding molecule inducing immune response to target antigen

摘要

In a living body to which an antigen-binding molecule comprising an antigen-binding domain whose antigen-binding activity is changed depending on the ion concentration condition and an FcRn-binding domain having FcRn-binding activity under the conditions of a neutral pH range, It was found that an immune response to the antigen is being induced. In addition, the present inventors in a living body to which an antigen-binding molecule comprising an antigen-binding domain whose antigen-binding activity changes depending on the ion concentration and an FcRn-binding domain having FcRn-binding activity under the conditions of a neutral pH range , It was found that an immune response to the antigen was induced, and at the same time, the antigen-binding molecule had both an injury or proliferation inhibitory action against foreign species or cancer cells that express the antigen to which the antigen-binding molecule binds.