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Novel bio-conjugation kit using bifunctional linker and Cys-tagged SpyTag/Catcher for ADC
Novel bio-conjugation kit using bifunctional linker and Cys-tagged SpyTag/Catcher for ADC
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机译:新的生物缀合试剂盒,使用双官能接头和综合的血小节/捕集器进行ADC
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摘要
As a linker for stable conjugation of antibodies and drugs in the development of ADCs, a new conjugation kit with more stable and high conjugation efficiency is disclosed that improves the disadvantages of the conventional chemical conjugation method and the post-translation conjugation method. The present invention is a conjugation kit between antibodies and drugs for the formation of antibody-drug conjugates (ADC), comprising: a cysteine-tagged (Cys-Tagged) spy tag (SpyTag) oligopeptide; Cysteine-tagged (Cys-Tagged) SpyCatcher protein; And a bifunctional linker conjugated to a thiol group of the cysteine of the spy tag or the spy catcher.
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