METHOD FOR SCREENING DRUG AND THERAPEUTIC TARGET USED FOR TREATING ALZHEIMER'S DISEASE

摘要

The content described herein is by inhibiting and down-regulating the amount of PI4KIIIα protein, RBO/EFR3/EFR3A/EFR3B membrane protein, TTC7 protein, and the membrane protein complex formed by the protein or related enzyme activity that promotes Aβ secretion by neuronal cells. It is the use of genetic means or related inhibitors to reduce AD model Drosophila and mouse neuronal dysfunction by reducing Aβ accumulation in neurons.