GREEN CHEMICAL PREPARATION METHOD FOR ALPHA-TRI-O-ACETYL GLUCURONIC ACID METHYL ESTER BROMO COMPOUND

摘要

Provided is a green chemical preparation method for alpha-tri-O-acetyl glucuronic acid methyl ester bromo compound. The method uses sodium bromide, sulfuric acid and methyl tertiary ether system to replace the traditional hydrobromic acid or titanium bromide; the systemic reaction is clean; a product can be crystallized and separated directly from the system, the product has a high yield and a high purity; the sodium sulfate as a by-product can be recycled; and the distilled methyl tertiary ether and the concentrated mother liquor after crystallization and separation can be recycled, so as to achieve zero emission and free of pollution. The method can be used for large-scale preparation of alpha-tri-O-acetyl glucuronic acid methyl ester bromo compound, facilitating the development and production of glucuronic acid related drugs and functional compounds.