IMMUNE ASSAY FOR MONITORING RESPONSE TO ONCOLYTIC VACCINIA VIRUS AND USES THEREOF

摘要

Provided herein are methods and compositions tor assaying vaccinia virus- specific T cell responses in a sample from a subject undergoing treatment with an oncolytic vaccinia virus. The compositions comprise custom peptide pools from known immunogenic vaccinia virus epitopes in an HLA-agnostic format to profile peripheral CD8+ T ceil responses.