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Generating mature lineages from induced pluripotent stem cells with MECP2 disruption
Generating mature lineages from induced pluripotent stem cells with MECP2 disruption
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机译:从诱导的多能干细胞产生成熟谱系,用MECP2中断
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摘要
Provided herein are methods for the efficient in vitro maintenance, expansion, culture, and/or differentiation of pluripotent cells with disruption of the MeCP2 gene into various erythroid, myeloid, lymphoid, or endoderm lineages, particularly mature erythrocytes. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the precursor cells.
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