CHEMICAL SEMI-SYNTHESIS METHOD FOR ARTEMISININ

摘要

Disclosed is a chemical semi-synthesis method for artemisinin (VI), the method comprising the specific steps of: (1) reacting dihydroartemisinic acid (I) with oxalyl chloride (II) to produce dihydroartemisinyl chloride (III); (2) reacting the dihydroartemisinyl chloride (III) with the dihydroartemisinic acid (I) to produce dihydroartemisinic anhydride (IV) via an acylation reaction; and (3) subjecting the dihydroartemisinic anhydride (IV) to a photo-oxidation reaction and an oxidative rearrangement reaction using a microchannel reactor to prepare the target product, artemisinin (VI). Compared with the prior art, the method has the advantages of high product yield and good product purity, stable process, mild reaction conditions, easy industrial production, etc.