Novel bispecific aptamer for inducing tumor or cancer cell death by complement factor recruitment and uses thereof

摘要

The present invention relates to a dual specific aptamer that induces target cell death by recruitment of a complement factor and a use thereof, and the dual specific aptamer of the present invention can be artificially synthesized at low cost, and thus, is a unit cost compared to conventional antibodies. Is inexpensive and has excellent biocompatibility. In addition, due to the dual specificity of the surface molecule and the complement factor of the target cell, the target cell is killed by recruiting the complement factor to target cells having immune resistance by inhibiting the recruitment of the complement factor, particularly tumors and cancer cells such as pancreatic cancer. Can induce. In addition, it is not degraded in vivo through an additional modification and remains active for a sufficiently long time, so that it can be effectively used for the prevention or treatment of tumors and cancers.