Oxysterols and how to use them

摘要

PROBLEM TO BE SOLVED: To provide a compound useful for prevention and treatment of various symptoms, to provide a compound according to formula (I), a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof; Medium, R1, R2, and R5 are as defined herein. The compounds of the present invention are expected to be useful in the prevention and treatment of various symptoms. Provided herein are substituted oxysterols useful for the prevention and / or treatment of a wide range of disorders, including but not limited to NMDA-mediated disorders. These compounds are expected to exhibit improved in vivo potency, pharmacokinetic (PK) properties, oral bioavailability, formulation suitability, stability and / or safety compared to other oxysterols. Further provided are pharmaceutical compositions containing the compounds of the invention and methods of their use and treatment. [Selection diagram] None