SYNTHESIS AND USAGE OF 1,2-DIAMINODIAMANTANE PLATINUM(II) COMPLEXES

摘要

A new bulky lipophilic chiral ligand based on 1,2-diaminodiamantane is revealed in both of its enantiomeric forms for the preparation of novel platinum(II) complexes. The R,R-enantiomer shows increased efficacy as compared to cisplatin. The binding of diamondoid-based platinum complexes to nucleotides occurs at similar or faster rate for both isomers compared to cisplatin so that the herein revealed platinum(II) complexes are compounds with high anti-cancerogenic activity .