COMBINATION OF IMMUNE-MODULATORS WITH TUMOR SPECIFIC NEOANTIGENS FOR USE IN PREVENTION AND TREATMENT OF TUMORS

摘要

The present invention relates to a personalized vaccine with antitumor activity against neoantigens, administered in combination with immune-modulator agents, in particular with an anti-CTLA-4 antibody, to treat a neoplasia or prevent the relapse of a neoplasia.