ORAL SOLID FORMULATION COMPRISING PYRIDOPYRIMIDIN-BASED HYDROCHLORIDE AND PREPARATION METHOD THEREOF

摘要

The present invention is 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidine-5(6H) -On hydrochloride can be used together with a specific carrier to provide an oral solid preparation with excellent stability and drug dissolution rate. Furthermore, the oral solid preparation can be usefully commercialized as a pharmaceutical composition for the treatment of proliferative diseases.