MiRNA bio-marker for non-invasive differential diagnosis of acute rejection in kidney transplanted patients and uses thereof

摘要

The present invention provides 8 kinds of miRNAs, miR-4488, miR-4532, miR-146a-5p, miR-21-5p, miR-373-3p, miR-31-5p, miR-223-3p, miR-210- 3p and a marker composition for diagnosing acute renal rejection reaction comprising at least one miRNA selected from the group consisting of a combination thereof as a marker, a method of providing information necessary for diagnosis of acute renal transplantation using the marker composition, the marker It relates to a diagnostic composition comprising an agent for measuring the expression level of, and a diagnostic kit comprising a quantification device for the marker. MiR-4488, miR-4532, miR-146a-5p, miR-21-5p, miR-373-3p, miR-31-5p, miR-223-3p and miR-210-3p according to the present invention are kidney transplants Since it is present at a high level in the urine of patients with acute rejection, it can be used to conveniently diagnose acute kidney transplant rejection by a non-invasive method.