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Rubella Virus Spike Construct

机译:风疹病毒尖峰结构

摘要

Rubella virus antigen, characterized in that it is a rubella virus E1-E2 envelope protein complex construct (synonym: rubella spike construct), comprising at least one E1 component and one E2 component which are connected - wherein the E1 component consists of the E1 coat protein, whose C-terminal transmembrane region and intravirional domain are removed and whose N-terminus comprises the ectodomain of the E1 coat protein, - and where the E2 component consists of the E2 coat protein , whose transmembrane regions and intravirional domain are removed and whose N-terminus comprises the ectodomain of the E2 coat protein, - and the C-terminus of the E2 component is connected to the N-terminus of the E1 component directly or by means of a linker.
机译:Rubella病毒抗原,其特征在于它是一种风疹病毒E1-E2包络蛋白复杂构建体(同义词:风疹峰值构建体),包括至少一个连接的E1组分和一个E2组分 - 其中E1组分由E1涂层组成除去其C-末端跨膜区域和蛛网孔结构域的蛋白质,其N-末端包括E1涂层蛋白的突突 - 以及E2组分由E2涂层蛋白组成的,其跨境区域被移除并且其N-末端包括E2涂层蛋白的外胚瘤, - E2组分的C-末端直接或通过接头连接到E1组分的N-末端。

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