SYSTEMS AND METHODS FOR PLANNING, CONTROLLING AND/OR DELIVERING RADIOTHERAPY AND RADIOSURGERY USING COMBINED OPTIMIZATION OF DYNAMIC AXES (CODA)

摘要

Methods and systems for radiation treatment planning and delivery apply a CODA cube. Cost values in the CODA cube may be used in the optimization of couch, collimator, and gantry angles simultaneously. Trajectories generated using the CODA cube show significant benefits when compared to conventional VMAT. A statistically significant sparing to OAR maximum radiation doses was seen. CODA plans resulted in a reduction to maximum radiation dose in OARs of 20.6% (p < 0.01), with maximum brainstem radiation dose decreased by 2.63 Gy (p = 0.031) on average. Mean reduction in total MU was 8.6% (p = 0.156), and a mean decrease in non-target brain tissue receiving 12 Gy or higher was 3.9% (p = 0.16), when compared to standard VMAT methods (n = 7).