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Spirocyclic compounds as tryptophan hydroxylase inhibitors
Spirocyclic compounds as tryptophan hydroxylase inhibitors
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机译:螺环化合物作为色氨酸羟化酶抑制剂
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摘要
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.
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