The present invention, including the crystalline form, (8 S ,9 R )-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1 H -1,2,4-triazole -5-yl) -8,9-dihydro-2 H -pyrido[4,3,2- de ]phthalazine-3(7 H )-one tosylate salt forms, and methods for their preparation are provided. do. Further, (8 S ,9 R )-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1 H -1,2,4-triazol-5-yl)-8 , 9-dihydro -2 H - pyrido [4,3,2- de] phthalazine -3 (7 H) - and a pharmaceutical composition comprising an on-tosylate salt, treating a disease or condition, such as cancer, To (8 S ,9 R )-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1 H -1,2,4-triazol-5-yl)-8, 9-dihydro-2 H -pyrido[4,3,2- de ]phthalazine-3(7 H )-one tosylate salt is provided.
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机译：本发明，包括结晶形式，（8℃，9，r r℃）-5-氟-8-（4-氟苯基）-9-（1-甲基 - 1 H -1,2,4-三唑-5-y1） -8,9-二氢-2h - 吡啶[4,3,2- De ]酞菁-3（7℃/ h） - 酮盐盐形式，以及其制备方法。做。此外，（8℃/ s）-5-氟-8-（4-氟苯基）-9-（1-甲基-1， -1,2,4-三唑-5- y1）-8,9-二氢-2 h + - pyrido [4,3,2- de] 酞嗪-3（7℃） - 和药物组合物，其包含甲苯甲磺酸盐盐，治疗疾病或病症，例如癌症，（8 S ，9 r r℃-5-氟-8-（4-氟苯基）-9-（1-甲基-1 H -1,2,4-三唑-5-基） - 8,9-二氢-2 H磷嗪-3（7℃/酮）酞甲磺酸盐[4,3,2- ]酞菁提供盐。
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