NANOPARTICLE HAVING CGAS-STING PATHWAY ACTIVATION FUNCTION, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

摘要

A nanoparticle having the cGAS-STING activation function. The nanoparticle is an organic-inorganic hybrid nanoparticle containing a metal ion. The metal ion has the cGAS-STING activation function. The nanoparticle comprises a macromolecule and the metal ion, and is formed by the interaction of the macromolecule with the metal ion and a negative ion. Moreover, the macromolecule can protect the colloidal stability of the nanoparticle. The nanoparticle can effectively trigger the production of STING-dependent type I interferon, and can be administered to a subject using different routes (comprising intravenous therapy, intramuscular injection, intradermal injection, intranasal injection, etc.). A nanoparticle preparation can be used for treating disorders and diseases that are beneficial in regulating STING activity, such as infectious diseases, cancer, inflammation, allergic and autoimmune diseases, and precancerous syndromes. The nanoparticle can also be used for triggering the immune response, and can be used as a vaccine adjuvant.