OSTEOGENIC GROWTH PEPTIDE CARBON-TERMINAL PENTAPEPTIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

摘要

The present invention provides an osteogenic growth peptide carbon-terminal pentapeptide derivative, a preparation method therefor, and use thereof. The osteogenic growth peptide carbon-terminal pentapeptide derivative includes one or more of H-Dopa-Gly-Phe-Gly-Gly-OH, H-D-Tyr-Pro-D-Phe-Gly-Gly-OH, Cyclo(Gly-Gly-D-Phe-Pro-D-Tyr), Cyclo(Tyr-Gly-D-Phe-Gly-Gly), Cyclo(D-Tyr-Gly-Phe-Gly-Gly), Cyclo(Gly-Gly-D-Phe-Gly-Tyr), and Cyclo(Gly-Gly-Phe-Gly-D-Tyr). Said derivative retains pharmacophores Tyr10 and Phe12 of the original pentapeptide in the structure, and have the structural feature of improving metabolic stability.