Genetically engineered NK cell lines transduced with a polynucleotide encoding novel chimeric antigen receptor and use thereof

摘要

The present invention is a cancer antigen-specific chimeric antigen receptor (chimeric antigen receptor) comprising a cancer antigen-specific monoclonal antibody or a functional fragment thereof, a transmembrane domain, and a CD3ζ domain of a T cell receptor for more efficient immunotherapy of solid cancer. CAR) A host immune cell is transformed to express a protein, and a genetically modified immune cell and use thereof are provided.