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COMPOSITIONS AND METHODS OF IMMUNOTHERAPY TARGETING TIGIT AND/OR CD112R OR COMPRISING CD226 OVEREXPRESSION
COMPOSITIONS AND METHODS OF IMMUNOTHERAPY TARGETING TIGIT AND/OR CD112R OR COMPRISING CD226 OVEREXPRESSION
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机译:靶向TIGIT和/或CD112R或包含CD226过表达的组合物和方法
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摘要
The present disclosure provides compositions for treating solid tumors, including modified immune cells that specifically target tumor-associated antigens for immunotherapies, wherein expression or activity of T cell immunoreceptor with Ig and ITIM domains (TIGIT) and/or CD112R in the modified immune cells is inhibited to improve antitumor functionality of the cells. Alternatively, CD226 is overexpressed in such modified immune cells. Also provided are methods for treating solid tumors, such as tumors formed by common epithelial cancers.
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