首页>
外国专利>
RESTRICTIVE INVERTED TERMINAL REPEATS FOR VIRAL VECTORS
RESTRICTIVE INVERTED TERMINAL REPEATS FOR VIRAL VECTORS
展开▼
机译:限制倒置末端对病毒载体的重复
展开▼
页面导航
摘要
著录项
相似文献
摘要
This invention relates to modified parvovirus inverted terminal repeats (ITRs) that do not functionally interact with wild-type large Rep proteins, synthetic Rep proteins that functionally interact with the modified ITRs, and methods of using the same for delivery of nucleic acids to a cell or a subject. The modifications provide a novel Rep-ITR interaction that limits vector mobilization, increasing the safety of viral vectors.
展开▼