首页>
外国专利>
COLLAFIT MENISCAL SCAFFOLD: COMPOSITE MADE OF POLYURETHANE AND OTHER POLYMERS, WITH HUMAN COLLAGEN COMBINED WITH PLANT COLLAGEN, BIODEGRADABLE AND COLONISABLE, IN ADVANCED ARTHRITIS OF THE KNEE
COLLAFIT MENISCAL SCAFFOLD: COMPOSITE MADE OF POLYURETHANE AND OTHER POLYMERS, WITH HUMAN COLLAGEN COMBINED WITH PLANT COLLAGEN, BIODEGRADABLE AND COLONISABLE, IN ADVANCED ARTHRITIS OF THE KNEE
The present invention relates to a composite implant made of polyurethane, of two polymers PCA e PLGA, with peripheral reinforcement, with biomechanics close to the normal meniscus, with resistance to traction, pressure and tearing, and preventing the pores from collapsing. under condyle-tibia pressure; and with layers integrated by cross linking and lyophilization or 3D printing, of Rh Collagen, human recombinant collagen prepared from plant plants, which is porous foam, biodegradable and which serves as a scaffold for the repair or replacement of the destroyed meniscus, indicated in grade 3 or 4 terminal osteoarthritis of the knee, for the prevention or regenerative treatment of advanced osteoarthritis of the knee, to avoid knee replacement in young patients. The implant of the present invention is biocompatible as well as the degradation products. The present invention also provides a process for manufacturing these biocompatible implants. Allen PR, Denham RA, Swan AV. Late degenerative changes after meniscectomy: factors affecting the knee after operation. J Bone Joint Surg Br. 1984; 66 (5): 666-671.2. 1. Allen PR, Denham RA, Swan AV. Late degenerative changes after meniscectomy: factors affecting the knee after operation. J Bone Joint Surg Br. 1984; 66 (5): 666-671.3. 38. Steadman JR, Rodkey WG. Tissue-engineered collagen meniscus implants: 5- to 6-year feasibility study results. Arthroscopy. 2005; 21 (5): 515-525.4. Efe T, Getgood A, Schofer MD, et al. The safety and short-term efficacy of a novel polyurethane meniscal scaffold for the treatment of segmental medial meniscus deficiency. Knee Surg Sports Traumatol Osteoarthritis. 2012; 20 (9): 1822-1830.5. Baek J, Jin S, Sovani S, Chen X, D'Lima DD, Grogan SP. Meniscal tissue engineering: cell encapsulation of electrospun collagen. Paper presented at: Orthopedic Research Society Annual Meeting, 2014; New Orleans, LA. http://www.ors.org/Transactions/60/0225.pdf.6. Freymann U, Endres M, Neumann K, Scholman HJ, Morawietz L, KapsC. Expanded human meniscus-derived cells in 3-D polymer-hyaluronan scaffolds for meniscus repair. Acta Biomater. 2012; 8 (2): 677-685.16. Article Dr Assor: knee osteoarthritis and mesenchymal stem cells: can knee prosthesis be avoided; communication Sofcot Paris 201417. Artificial meniscus - Google Patents US20170202672A1; Persaud18. Elsner, JJ; Zur, G .; Guilak, F .; et al.; Poster 1057, 56 th Annual Meeting of the Orthopedic Research Society19. Response of hPDLSCs on 3D printed PCL / PLGA composite scaffolds in vitro; Caixia Peng, Jinxuan Zheng, Dongru Chen, Xueqin Zhan, Lidi Deng, Zhengyuan Chen, Liping Wu; Published on line May 25, 2018 https://doi.org/10.3892/mmr.2018.907620. Synthesis of polycarbonate urethane elastomers and effects of chemical structures on their thermal, mechanical and biocompatibility properties; Rong Zhu, Yiyu Wang, Zongrui Zhang, Daiwei Ma, and Xinyu Wang21. Short-term evaluation of an anatomically shaped polycarbonate urethane total meniscus replacement in a goat model; ACT Vrancken, W. Madej, G. Hannink, N. Verdonschot, TG van Tienen, P. Buma; https://doi.org/10.1371/journal.pone.0133138; PLoS ONE 10 (7): Jul 20, 201522. Poly (epsilon-caprolactone) and poly (L-lactic-co-glycolic) degradable polymeric sponges attenuate astrocyte response and lesion growth in acute traumatic brain injury. Wong DY 1 , Hollister SJ, Krebsbach PH, Nosrat C; Tissue Enq. 2007 Oct; 13 (10): 2515-2323. Scheller et al., Arthroscopy 17: 946-52 (2001) 24. Artificial meniscus Polycarbonate and synthetic Kevlar fibers - Google Patents US20170202672A1Dr Michel Assor, applicant.New version of patent application canceling and replacing the previous FILED VIA WEBFORM Orthopedic Surgeon 11 bd Pugette, 13009 Marseille, France Institut du Genou Arthrosport 0033609505060]
展开▼