Anticancer Salmonella Bio-synthesizing and Secreting Indirubin and Anticancer Composition Comprising the Salmonella

摘要

The present invention relates to a novel Salmonella strain that can be effectively used for anticancer therapy by biosynthesizing and secreting indirubin, which is targeted to the tumor site and has anticancer activity, and induces immune stimulation, and to an anticancer composition comprising the same, more specifically The present invention relates to an anticancer attenuated Salmonella strain that is transformed with a gene construct including a fmo (flavin-containing monooxygenase) gene and a tnaA (tryptophanase) gene to produce indirubin at a cancer site, and an anticancer composition comprising the same.