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ASSAYS FOR DETECTING AND QUANTIFYING A BIOMARKER OF PERICYTE INJURY
ASSAYS FOR DETECTING AND QUANTIFYING A BIOMARKER OF PERICYTE INJURY
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机译:用于检测和定量单性损伤生物标志物的测定
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摘要
A highly sensitive immunoassay has been developed and validated. In various embodiments, the assay comprises an immunoassay usable to measure soluble PDGFRβ (sPDGFR-β) in a human biofluid sample such as cerebrospinal fluid (CSF). In various embodiments, elevated sPDGFR-β in a human biofluid sample reflects pericyte and blood-brain barrier (BBB) injury, and is therefore an early biomarker of human cognitive dysfunction, dementia, and/or Alzheimer's disease.
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