COMBINATION OF METFORMIN AND CYCLOPHOSPHAMIDE AS AN ADJUVANT IN CANCER IMMUNOTHERAPY

摘要

The present invention relates to a combination comprising metformin and cyclophosphamide for use with an immunotherapy in the treatment of a solid cancer. In particular, said combination comprising metformin and cyclophosphamide is used as an adjuvant for an immunotherapy. The present invention relates more specifically to a combination comprising metformin and cyclophosphamide for use with an adoptive cell therapy, with a therapeutic vaccine, with a checkpoint inhibitor therapy or with a T-cell agonist therapy, preferably with an adoptive cell therapy or a checkpoint inhibitor therapy, in the treatment of a solid cancer.