A method of making an antibiotic agent for streptomycin which comprises reacting a substance from the group consisting of streptomycin and its derivatives having the characteristic aldehyde-carbonyl group of the steptose with a straight chain aliphatic alpha amino mercapto compound in a reaction medium solvent then reduce this reaction product with raney nickel to produce an antibitically active substance which differs from the starting material because the carbonyl group of streptose is substituted by a substituent of the class consisting of substituted methylene amino and methylene amino substituted methylenic groups of the lower alcohole series and recover this hydrogenated compound from the reaction mixture. (Machine-translation by Google Translate, not legally binding)
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