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A procedure for the preparation of new barbituric acids and tiobarbitus acids dissolved in position 5, 5 and of their salts. (Machine-translation by Google Translate, not legally binding)
A procedure for the preparation of new barbituric acids and tiobarbitus acids dissolved in position 5, 5 and of their salts. (Machine-translation by Google Translate, not legally binding)
Process for the preparation of new barbituric acids and thiobarbituric acids disubstituted in position 5,5 and their salts, characterized in that compounds of the general formula are prepared ** (See formula) ** where they mean X an alkyl or alkenyl radical of low molecular weight, And hydrogen an alkyl or alkenyl radical of low molecular weight, and Z oxygen or sulfur, condensing functional derivatives suitable for reacting disubstituted malonic acids of general formula ** (See formula) ** particularly nitriles of monoesters, or diesters, with urea, ethers of isourea, thiourea or guanidine, with their N-alkyl- or N-alkenyl-derivatives of low molecular weight or with N-acyl derivatives of those mentioned first as well as last place, particularly cyanoguanidine (dicyandiamide) or N-methyl-N'-acetyl-urea, by which the monoimines of barbituric acids or thiobarbituric acids, possibly obtained first, are converted to the diimines, cyanomonoimines or cyano-diimines of barbituric acids by hydrolysis in the respective barbituric acids or thiobarbituric acids, and by transposing, if desired, before or after the eventual hydrolysis barbituric acids or non-alkyl- or alkenyl-substituted intermediates at any ring nitrogen atom, with one mole of a means of alkylation or alkenylation in the presence of an acid-binding medium, as well as the transformation, if desired, of barbituric acids or thiobarbituric acids obtained in their salts with inorganic or organic bases. (Machine-translation by Google Translate, not legally binding)
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