首页> 外国专利> A procedure for the preparation of new a-nor b-homo steroids (Machine-translation by Google Translate, not legally binding)

A procedure for the preparation of new a-nor b-homo steroids (Machine-translation by Google Translate, not legally binding)

机译:新的a-nor b-homo类固醇的制备程序(由Google Translate进行机器翻译,不具有法律约束力)

摘要

A process for the preparation of new A-nor B-homo steroids, characterized in that 19-nor-3-methoxy 20-hydroxy δ2.5 (10) -pregnadiene is oxidized by the action of aluminum isopropylate, is isolated -nor 3-methoxy 20-oxo δ2,5 (10) -pregnadiene, the latter is treated with an acidic agent to obtain 19-nor 3,20-dioxo δ5 (10) -pregneno, is actuated ozone on this compound, 3,5,10,20 -tetroxo 5,10-dry 19-nor pregnane is isolated, which is cyclized by acid treatment, obtaining the 3,6,20-trioxo A-nor B-homo δ 5 (10) 19-nor pregnene, the latter is selectively reduced by the action of an alkaline mixed hydride, and 3,6,20-trioxo A-nor B-homo 10 ξ9-nor pregnane. (Machine-translation by Google Translate, not legally binding)
机译:一种新的A-nor B-homo类固醇的制备方法,其特征在于,通过异丙基铝酸的作用将19-nor-3-甲氧基20-羟基δ2.5(10)-孕二烯氧化成-nor 3 -甲氧基20-氧代δ2,5(10)-孕二烯,用酸性剂处理以获得19-nor 3,20-二氧代δ5(10)-孕烯,在该化合物上被激活的臭氧为3,5,分离出10,20-trotrox 5,10-干燥的19-nor孕烯,通过酸处理将其环化,得到3,6,20-trioxo A-nor B-homoδ5(10)19-nor孕烯,后者通过碱性混合氢化物和3,6,20-trioxo A-nor B-homo 10ξ9-nor孕烯的作用选择性还原。 (通过Google翻译进行机器翻译,没有法律约束力)

著录项

  • 公开/公告号ES278332A1

    专利类型

  • 公开/公告日1962-08-16

    原文格式PDF

  • 申请/专利权人 ROUSSEL-UCLAF;

    申请/专利号ES19620278332

  • 发明设计人

    申请日1962-06-15

  • 分类号C07J61;C07J69;C07J75;

  • 国家 ES

  • 入库时间 2022-08-23 18:05:14

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