New androstane and 19-nor-androstane derivatives and the preparation thereof

摘要

The invention comprises steroids of the general formula: FORM:0962674/C1/1 wherein R1 represents H, CH3; R2 represents H, Cl or OH; R3 represents H, H or a H, b OH or keto; R4 represents H, F; R5 represents H, H or CH2; X represents H, OH or =N -CH2CH2OH; Y represents H, H or a H, b OH or a CH3, b -OH or a C2H5, b OH or =N-CH2 CH2OH (at least one of the symbols X and Y represents =N-CH2CH2CH2OH) and the corresponding derivatives unsaturated in the 1, 2-, 4, 5- or 5, 6-position or in the 1, 2- and 4, 5-positions, and the preparation thereof by reacting the required 3-keto, 17-keto or 3, 17-diketo steroids with b -hydroxyethylamine. Therapeutic compositions having androgenic or anobolic activity and which may be administered orally contain as the active ingredient steroids of the above general formula.