A process for preparing N dihydrolysergol-alkylcarbaminsyreestere of I and 1-methyl-dihydrolysergol I.

摘要

The invention c omprises ergoline I derivatives of the general formula F1 wherein, when R is a hydrogen atom, R1 is an acyl radical of an alkanoic or carbomoic carboxylic acid having from 3-10 carbon atoms or an unsubstituted aromatic or a pyridine carboxylic acid, and, when R is a methyl group, R1 is a hydrogen atom or an acyl radical as just defined, and the preparation thereof by esterification of the corresponding 8-hydroxymethy-ergoline I derivative with the appropriate acid halide or anhydride; the 1,6dimethyl -8-hydroxymethyl-ergoline I being prepared by reaction in liquid ammonia of methyl iodide with the potassium salt of the 6-methyl8-hydroxymethyl-ergoline I which is itself prepared by reduction with lithium aluminium hydride of an ester of dihydrolysergic acid. Therapeutic compositions for oral or parenteral administration, having oxytocic, antienteraminic, andrenolytic, hypotensive and sedative activity, comprise a compound of the above general formula and an excipient or diluent. Reference has been directed by the Comptroller to Specification 1,008,466.