A procedure for preparing compounds with stimulating properties of the nervous system. (Machine-translation by Google Translate, not legally binding)

摘要

A procedure for preparing a compound of formula I **(See formula)** wherein R is methyl or hydrogen, which comprises forming an alkali metal salt of a 3-phenylindene, by reaction of 3-phenylindene with a strongly alkaline material, such as sodium amide, sodium hydride, lithium amide, butyl lithium, sodium triphenylmethyl, and reacting with it a compound of group A. 2-dimethylaminoethyl halide and B. ester of N- (2-haloethyl) -N-methylcarbamic acid, said halogens being selected from the group of chlorine, bromine and iodine, in which an intermediate of formula II is produced, in which R1 is a lower alcohol group of up to 6 carbon atoms, when compound B is used as the reactant, **(See formula)** or alternatively forming said intermediate of formula II by reacting said compound of formula I, wherein R is CH3, with an alcohol haloformate of formula XCO2R1, wherein X is selected from the group consisting of chlorine, bromine and iodine, at a temperature of 80-150ºC in the presence of an inert organic solvent, and thereafter hydrolyzing and decarboxylating said intermediate of formula II to provide the compound of formula I in which R is hydrogen. (Machine-translation by Google Translate, not legally binding)