Procedure for the synthesis of benzofuran derivatives. (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for the synthesis of benzofuran derivatives, of the general formula ** (See formula) ** wherein S represents mono-, di- or tri-lower alkyl substitution, R represents a lower alkyl group and the dashed line denotes an optional bond, and its acid addition salts, characterized in reacting a halohydrin of the general formula ** (See formula) ** where S has the above meaning and X is chlorine or bromine, or an epoxide of the general formula ** (See formula) ** wherein S has the meaning set forth above, with an amine of the general formula R-NH2 (III) wherein R has the meaning set forth above, and, if desired, hydrogenating the resulting benzofuran derivative into the respective 2,3-dihydro-benzofuran; or by catalytically hydrogenated, in one or two steps, a 2- (2-lower alkylamino-1-hydroxy-ethyl) -benzofuran, whose benzene nucleus is substituted by lower alkyl and halogen or substituted by lower alkenyl or substituted by lower alkyl and lower alkenyl, and, if desired, converting the resulting base into an acid addition salt. (Machine-translation by Google Translate, not legally binding)