A procedure for preparing new topic aminoalcohylates of dibenzo (-a, d) ciclohepten-5-onas. (Machine-translation by Google Translate, not legally binding)

摘要

A process for preparing compounds of the general formula ** (See formula) ** wherein Z is -CH = CH- or -CH2-CH2-, X and Y are hydrogen, halogen, lower alkyl, S-lower alkyl, O-lower alkyl, methylenedioxy and trifluoromethyl, B is a straight chain alkyl group or branched from 1 to 8 carbon atoms, and Am is a member selected from piperazino, 4-lower alkyl piperazino, 4-hydroxy lower alkyl piperazino, pyrrolidino, piperidino and ** (See formula) ** , wherein R1 and R2 are hydrogen, lower alkyl, phenyl and phenyl lower alkyl, the process comprising ** (See formula) ** (a) reacting a compound of the general formula ** (See formula) ** with a base, to form an oxime anion of the formula ** (See formula) ** and reacting said oxime anion with a compound of the formula AmB-D wherein D is halide or tosyloxy, to form the compounds wherein Am is a tertiary amino group, or (b) reacting an oxime anion of the formula ** (See formula) ** with a compound of the formula ** (See formula) ** wherein R1 is other than hydrogen and R3 is a dissociable group such as acyl, benzyl, trifluoroacetyl or carbobenzoxy, and then hydrolytically dissociating said R3 to form compounds of the formula (see formula) (Machine-translation by Google Translate, not legally binding)