A Process for the Manufacture of Benzdiaz1,4Epine Derivatives from Dibenzob,f1,5Diazocines and Certain Novel Dibenzob,f1,5Diazocinium Salts Useful therein

摘要

1,150,415. Dibenzodiazocine and benzodiazepine derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 26 July, 1966 [9 Aug., 1965], No. 33535/66. Heading C2C. Compounds of the general formula (RSP1,2,3/SP=halogen, CF 3 , NO 2 , CN, C 1-7 alkyl, C 1-7 alkoxy, C 1-7 alkylthio, C 1-7 alkylsulphinyl or C 1-7 alkylsulphonyl, RSP4/SP=benzyl or C 1-7 alkyl, RSP5/SP=C 1-7 alkyl and the broken lines denote optional substituents) are prepared by treating a compound of the formula with a quaternizing agent in which the labile group is a C 1-7 alkyl or benzyl group and reacting the resulting monoquatemary ammonium salt of the formula (RSP40/SP=C 1-7 alkyl or benzyl and X-=anion) or the resulting diquaternary ammonium salt of the formula with a compound of the formula (RSP6/SP=OH, NH 2 , C 1-7 alkoxy, or aryloxy) or salt thereof. The preparation of 2,8-dichloro-6,12-diphenyldibenzo [b,f][1,5] diazocine is described.