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A process for the preparation of 1-phenyl- or cyclohexyl-5- (γ-carboxypropyl, γ-hydroxy-n-butyl, β-acetylethyl- or γ-hydroxy-n-butyl) -barbitursyrer or salts thereof.
A process for the preparation of 1-phenyl- or cyclohexyl-5- (γ-carboxypropyl, γ-hydroxy-n-butyl, β-acetylethyl- or γ-hydroxy-n-butyl) -barbitursyrer or salts thereof.
1,159,271. Anti-inflammatory &c., medicines. TAKEDA CHEMICAL INDUSTRIES Ltd. 20 July, 1966 [21 July, 1965; 7 May, 1966], No. 32641/66. Heading A5B [Also in Division C2] Pharmaceutical compositions having antiinflammatory and uricosuric activity comprise, as active ingredient, at least one 1,5-disubstituted barbituric acid derivative of the general formula wherein R 1 is a S - hydroxy - n - butyl, - hydroxy - n - butyl or - carboxypropyl group and R 2 is a cyclohexyl or phenyl group, or pharmaceutically acceptable base addition salt thereof, optionally together with aminopyrine or a steroidal anti-inflammatory agent and optionally together with a pharmaceutically acceptable carrier therefor. The compositions may be administered orally, rectally or parenterally.
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